Indeed, it is the diversity of presentation, accumulation of manifestations over time, and undulating disease course that challenge the most astute of clinicians. Systemic lupus erythematosus is a chronic autoimmune condition that causes inflammation in the bodys tissues. If a patient meets at least four criteria, lupus can be diagnosed with 95% specificity and 85% sensitivity. Systemic lupus erythematosus is a systemic autoimmune disease with a worldwide distribution. Disease activity varies over time and, at the onset, symptoms are very general and. The slicc group is an international group of investigators dedicated to clinical research on sle. Systemic lupus erythematosus sle is a spectrum of autoimmune disease in which defects can occur at multiple points of the immune cascade, resulting in a striking heterogeneity of clinical. In the validation cohort, the new criteria had a sensitivity of 96. Although both men and women of all age groups can be affected, women outnumber men almost 10 fold and. Systemic lupus erythematosus is a disease that continues to evolve over time. All patients with lupus should receive education, counseling, and support.
New acr, eular criteria distinguish lupus from imitators. The most recent addendum to the classification criteria for sle dates from 2012, when the systemic lupus international collaborating clinics slicc group published a revision and validation of the acr criteria 5. Systemic lupus erythematosus is an autoimmune disease that affects many systems, including the skin, musculoskel. Hydroxychloroquine is the cornerstone of treatment because it reduces disease flares and other constitutional symptoms. Pdf toward new criteria for systemic lupus erythematosus. Researchers from around the world contributed to the development of classification criteria for systemic lupus erythematosus sle designed to distinguish the. The recent attempts to create modern criteria for the classification of sle have aimed at being more sensitive, clinically relevant and meaningful than the older american college of rheumatology acr classification criteria. With rare exception, the unifying laboratory abnormality is. Discoid rash raised erythematous patches with keratotic scaling, follicular plugging, and atrophic scarring 3. In 2012, the systemic lupus international collaborating clinics slicc network presented a set of criteria based on almost 1400 patient scenarios, including a derivation and a validation of the new criteria as well as of the 1997 acr classification. The diagnostic accuracies of the 2012 slicc criteria and. Thus, a patient who presents with skin and joint disease remains at risk for renal disease even after having lupus. Diagnostic criteria for systemic lupus erythematosus.
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